Organizing committee

Dr. Anna Valenti
Dr. Anna Valenti(+39) 0816132247
Affiliation: Institute of Biosciences and BioResources, National Research Council of Italy, Italy.
Research Interests: DNA metabolism and biochemical analysis of proteins and enzymes in particular related to DNA structure regulation and to the safeguard of genomic stability in thermophiles.
Anna Valenti graduated in Biological Science in 2004 at the University of Naples “Federico II and received her PhD in Applied Biology at the same Institute. Since to 2012 she is a permanent researcher at CNR-IBBR (Naples-Italy).
The research activities of Anna Valenti are mainly focused on biochemical studies of conserved proteins and enzymes involved in DNA transactions. During her PhD work and subsequently, she dedicated her activity to analyze the roles of proteins related to DNA structure regulation and to the safeguard of genomic stability. Pioneering studies have been carried out, in vivo and in vitro, on molecular adaptation to high temperatures by clarifying the role of peculiar DNA topoisomerases in thermophilic organisms.
The expertise acquired in the manipulation of DNA-enzymes has provided the basis to coordinate several studies on DNA interacting proteins, both in thermophilic and mesophilic organisms and to open international collaborations, which have led to achieve significant results in the field of: i) the interaction between human topoisomerases and small molecules; ii) the analysis of DNA topology at the nanometric level; iii) the link between DNA topology and DNA transcations; iv) in vivo and in vitro study of conserved DNA-alkyltransfares both in prokaryotes and eukaryotes. In the last years she was also interested in the biotechnological application by employing DNA active enzymes. She has long-term experience in DNA metabolism and biochemical analysis of proteins and enzymes in particular related to DNA structure regulation and to the safeguard of genomic integrity topoisemerases, helicases, DNA binding proteins) in model organism both prokaryotes and eukaryotes (bacteria, archaea, yeast, Caenorhabditis elegans).
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Prof. Giuseppe Perugino
Prof. Giuseppe Perugino(+39) 081679052
Affiliation: Department of Biology – University of Naples “Federico II”, Italy (BIO-UNINA)
Research Interests: Enzymatic characterization of DNA transaction enzymes and Carbohydrate Active Enzymes (CAZy).
Graduated in Biological Science in 1997 at the University of Naples “Federico II” and received his PhD in Biochemistry and Molecular Biology at the same University in 2003. In the 2008-2022 period was a permanent researcher at the Institute of Bioscience and BioResources of the National Research Council of Italy (CNR-IBBR, Naples). Since 2022, he is Assistant Professor of Biochemistry at the BIO-UNINA.

Main research activities:
– studies of glycosidases from (hyper)thermophilic microorganisms, in particular on their modification of the reaction mechanism, aimed to limit the hydrolysis and favoring the synthesis of oligosaccharides of high biotechnological interest;
– the biochemical and structural characterization of AGTs, enzymes involved in the genome stability that directly repair the DNA damage caused by alkylating agents. Particular focuses on: i) the development, for the first time, of new fluorescent assays; ii) by using these assays for the selection of new inactivators of the human AGT, involved in the tumor resistance to chemotherapies based on alkylating agents; iii) the application of the well-known SNAPtag® technology in vivo in extremophilic organisms by using mutated thermostable AGTs, and/or their in vitro employment in harsh reaction conditions, allowing an effective expansion of this technology; iv) the introduction of innovative protein-tags (ASL-tags) which allow a simultaneous in vivo immobilization and labelling of proteins/enzymes of interest (POI), avoiding of any purification procedures and allowing an indirect labelling of POIs for their in vivo localization. Furthermore, the production of two different ASL-tags make possible an innovative system to combine the activities of two POIs, putting this technology at the forefront of “biotech” applications.
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Dr. Roberto Defez
Dr. Roberto Defez(+39) 3474087227
Affiliation: Institute of Biosciences and Bioresources of the CNR in Naples
Roberto Defez directs the microbial biotechnology laboratory at the Institute of Biosciences and Bioresources of the CNR in Naples. He dworks on the nitrogen-fixing symbiosis between soil bacteria and legumes or cereals. He has published over 50 papers in peer reviewed journals, 5 patents and two copyright trademarks. Member of the National Academy of Agriculture; Member of the Ethics Committee of the Umberto Veronesi Foundation, Member of the Georgofili Academy; Elected member of the Scientific Council of the BioAgroFood Department of the CNR. He has written two books: Il Caso OGM, 2014 Carocci editore, runner-up at the 2015 Galileo Prize and SCOPERTA, how scientific research can help change Italy, Codice; Giancarlo Dosi Scientific Divulgation Award 2018 and third at the 2019 Galileo Prize.
Since 1998 involved in the public debate on the validity of GMOs, genetically modified organisms in agriculture, with interventions all focused on the scientific evaluation of the technical data available on the use of GMOs and on aspects of research policy, agricultural development, olive tree die-off Puglia for the Xylella epidemic or on evaluations on the use of glyphosate. He makes about thirty interventions a year on radio, newspapers and national television. He has completed 7 parliamentary hearings in 15 years and two hearings at the regional councils of the Puglia and Lombardy regions.
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Scientific committee