MARIA CIARAMELLA
PEER REVIEWD PUBLICATIONS 1985- 2019

  • Defez R*, VALENTI A*, Andreozzi A, Romano S, Ciaramella M, Pesaresi P, Forlani S, Bianco C. New Insights into Structural and Functional Roles of Indole-3-acetic acid (IAA): Changes in DNA Topology and Gene Expression in Bacteria. 2019 Sep 23;9(10). pii: E522. doi: 10.3390/biom9100522.
  • Bettotti P, Visone V, Lunelli L, Perugino G, Ciaramella M, Valenti A (2018). Structure and Properties of DNA Molecules Over The Full Range of Biologically Relevant Supercoiling States. Sci Rep. 18: 6163. doi: 10.1038/s41598-018-24499-5. 4
  • Serpe M, Forenza C, Adamo A, Russo N, Perugino G, Ciaramella M,Valenti A. (2019). The DNA Alkylguanine DNA Alkyltransferase-2 (AGT-2) Of Caenorhabditis Elegans Is Involved In Meiosis And Early Development Under Physiological Conditions.  Sci Rep. 9: doi: 10.1038/s41598-019-43394-1. 4
  • Miggiano R, Valenti A, Rossi F, Rizzi M, Perugino G, Ciaramella M. Every OGT Is Illuminated … by Fluorescent and Synchrotron Lights. Int J Mol Sci. 2017 Dec 5;18(12):2613. doi: 10.3390/ijms18122613
  • Visone V, Han W, Perugino G, Del Monaco G, She Q, Rossi M, Valenti A*, Ciaramella M*. (2017).  In vivo and in vitro protein imaging in thermophilic archaea by exploiting a novel protein tag.  PLoS One. Oct 3;12(10):e0185791. doi: 10.1371/journal.pone.0185791. eCollection 2017.
  • Morrone C, Miggiano R, Serpe M, Massarotti A, Valenti A, Del Monaco G, Rossi M, Rossi F, Rizzi M, Perugino G, Ciaramella M. Interdomain interactions rearrangements control the reaction steps of a thermostable DNA alkyltransferase. Biochim Biophys Acta. 2016 Oct 22;1861(2):86-96.
  • Ahmad M, Xue Y, Lee SK, Martindale JL, Shen W, Li W, Zou S, Ciaramella M, Debat H, Nadal M, Leng F, Zhang H, Wang Q, Siaw GE, Niu H, Pommier Y, Gorospe M, Hsieh TS, Tse-Dinh YC, Xu D, Wang W. RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals. Nucleic Acids Res.  2016 Jul 27;44(13):6335-49. doi: 10.1093/nar/gkw508.
  • De Falco M, Catalano F, Rossi M, Ciaramella M, De Felice M. NurA Is Endowed with Endo- and Exonuclease Activities that Are Modulated by HerA: New Insight into Their Role in DNA-End Processing. PLoS One. 2015 Nov 11;10(11):e0142345.doi: 10.1371/journal.pone.0142345.
  • Miggiano R, Perugino G, Ciaramella M, Serpe M, Rejman D, Páv O, Pohl R, Garavaglia S, Lahiri S, Rizzi M, Rossi F. Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled onto damaged DNA. Biochem J. 2016 Jan 15;473(2):123-33. doi: 10.1042/BJ20150833.
  • Vettone A, Serpe M, Hidalgo A, Berenguer J, del Monaco G, Valenti A, Rossi M, Ciaramella M, Perugino G. A novel thermostable protein-tag: optimization of the Sulfolobus solfataricus DNA- alkyl-transferase by protein engineering. Extremophiles. 2016 Jan;20(1):1-13. doi: 10.1007/s00792-015-0791-9.
  • Perugino G, Miggiano R, Serpe M, Vettone A, Valenti A, Lahiri S, Rossi F, Rossi M, Rizzi M, Ciaramella M. Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein. Nucleic Acids Res. 2015 Oct 15;43(18):8801-16. doi: 10.1093/nar/gkv774.
  • Visone V, Vettone A, Serpe M, Valenti A, Perugino G, Rossi M, Ciaramella M. Chromatin structure and dynamics in hot environments: architectural proteins and DNA topoisomerases of thermophilic archaea. Int J Mol Sci. 2014 Sep 25;15(9):17162-87. doi: 10.3390.
  • Vettone A, Perugino G, Rossi M, Valenti A, Ciaramella M. Genome stability: recent insights in the topoisomerase reverse gyrase and thermophilic DNA alkyltransferase. Extremophiles. 2014 Sep;18(5):895-904. doi: 10.1007/s00792-014-0662-9.
  • Jamroze A, Perugino G, Valenti A, Rashid N, Rossi M, Akhtar M, Ciaramella M. The reverse gyrase from Pyrobaculum calidifontis, a novel extremely thermophilic DNA topoisomerase endowed with DNA unwinding and annealing activities. J Biol Chem. 2014 Feb 7;289(6):3231-43. doi: 10.1074/jbc.M113.517649.
  • Miggiano R, Casazza V, Garavaglia S, Ciaramella M, Perugino G, Rizzi M, Rossi F. Biochemical and structural studies of the Mycobacterium tuberculosis O6-methylguanine methyltransferase and mutated variants. J Bacteriol. 2013 Jun;195(12):2728-36. doi: 10.1128/JB.02298-12.
  • Valenti A, De Felice M, Perugino G, Bizard A, Nadal M, Rossi M, Ciaramella M. Synergic and opposing activities of thermophilic RecQ-like helicase and topoisomerase 3 proteins in Holliday junction processing and replication fork stabilization. J Biol Chem. 2012 Aug 31;287(36):30282-95. doi: 10.1074/jbc.M112.366377.
  • Perugino G, Vettone A, Illiano G, Valenti A, Ferrara MC, Rossi M, Ciaramella M. Activity and regulation of archaeal DNA alkyltransferase: conserved protein involved in repair of DNA alkylation damage. J Biol Chem. 2012 Feb 3;287(6):4222-31. doi: 10.1074/jbc.M111.308320.
  • Valenti A, Perugino G, Rossi M, Ciaramella M. Positive supercoiling in thermophiles and mesophiles: of the good and evil. Biochem Soc Trans. 2011 Jan;39(1):58-63. doi: 10.1042/BST0390058.
  • Valenti A, Perugino G, Varriale A, D’Auria S, Rossi M, Ciaramella M. The archaeal topoisomerase reverse gyrase is a helix-destabilizing protein that unwinds four-way DNA junctions. J Biol Chem. 2010 Nov 19;285(47):36532-41. doi: 10.1074/jbc.M110.169029.
  • Valenti A, Perugino G, Nohmi T, Rossi M, Ciaramella M. Inhibition of translesion DNA polymerase by archaeal reverse gyrase. Nucleic Acids Res. 2009 Jul;37(13):4287-95. doi: 10.1093/nar/gkp386.
  • Perugino G, Valenti A, D’amaro A, Rossi M, Ciaramella Reverse gyrase and genome stability in hyperthermophilic organisms. Biochem Soc Trans. 2009 Feb;37(Pt 1):69-73. doi: 10.1042/BST0370069.
  • D’Amaro A, Valenti A, Napoli A, Rossi M, Ciaramella M. The prefoldin of the crenarchaeon Sulfolobus solfataricus. Protein Pept Lett. 2008;15(10):1055-62.
  • Valenti A, Perugino G, D’Amaro A, Cacace A, Napoli A, Rossi M, Ciaramella M. Dissection of reverse gyrase activities: insight into the evolution of a thermostable molecular machine. Nucleic Acids Res. 2008 Aug;36(14):4587-97. doi: 10.1093/nar/gkn418.
  • D’Amaro A, Rossi M, Ciaramella M. Reverse gyrase: an unusual DNA manipulator of hyperthermophilic organisms. Ital J Biochem. 2007 Jun;56(2):103-9.
  • Romano V, Napoli A, Salerno V, Valenti A, Rossi M, Ciaramella M. Lack of strand-specific repair of UV-induced DNA lesions in three genes of the archaeon Sulfolobus solfataricus. J Mol Biol. 2007 Jan 26;365(4):921-9.
  • Valenti A, Napoli A, Ferrara MC, Nadal M, Rossi M, Ciaramella M. Selective degradation of reverse gyrase and DNA fragmentation induced by alkylating agent in the archaeon Sulfolobus solfataricus. Nucleic Acids Res. 2006 Apr 14;34(7):2098-108. Print 2006.
  • Ciaramella M, Napoli A, Rossi M. Another extreme genome: how to live at pH 0. Trends Microbiol. 2005 Feb;13(2):49-51.
  • Napoli A, Valenti A, Salerno V, Nadal M, Garnier F, Rossi M, Ciaramella M. Functional interaction of reverse gyrase with single-strand binding protein of the archaeon Sulfolobus. Nucleic Acids Res. 2005 Jan 26;33(2):564-76.
  • Napoli A, Valenti A, Salerno V, Nadal M, Garnier F, Rossi M, Ciaramella M. Reverse gyrase recruitment to DNA after UV light irradiation in Sulfolobus solfataricus. J Biol Chem. 2004 Aug 6;279(32):33192-8.
  • Salerno V, Napoli A, White MF, Rossi M, Ciaramella M. Transcriptional response to DNA damage in the archaeon Sulfolobus solfataricus. Nucleic Acids Res. 2003 Nov 1;31(21):6127-38.
  • Rossi M, Ciaramella M, Cannio R, Pisani FM, Moracci M, Bartolucci S. Extremophiles 2002. J Bacteriol. 2003 Jul;185(13):3683-9.
  • Ciaramella M, Pisani FM, Rossi M. Molecular biology of extremophiles: recent progress on the hyperthermophilic archaeon Sulfolobus. Antonie Van Leeuwenhoek. 2002 Aug;81(1-4):85-97.
  • Napoli A, Zivanovic Y, Bocs C, Buhler C, Rossi M, Forterre P, Ciaramella M. DNA bending, compaction and negative supercoiling by the architectural protein Sso7d of Sulfolobus solfataricus. Nucleic Acids Res. 2002 Jun 15;30(12):2656-62.
  • Cobucci-Ponzano B, Moracci M, Di Lauro B, Ciaramella M, D’Avino R, Rossi M. Ionic network at the C-terminus of the beta-glycosidase from the hyperthermophilic archaeon Sulfolobus solfataricus: Functional role in the quaternary structure thermal stabilization. Proteins. 2002 Jul 1;48(1):98-106.
  • Moracci M, Trincone A, Cobucci-Ponzano B, Perugino G, Ciaramella M, Rossi M. Enzymatic synthesis of oligosaccharides by two glycosyl hydrolases of Sulfolobus solfataricus. Extremophiles. 2001 Jun;5(3):145-52.
  • Moracci M, Ciaramella M, Rossi M. Beta-glycosidase from Sulfolobus solfataricus. Methods Enzymol. 2001;330:201-15.
  • Napoli A, Kvaratskelia M, White MF, Rossi M, Ciaramella M. A novel member of the bacterial-archaeal regulator family is a nonspecific dna-binding protein and induces positive supercoiling. J Biol Chem. 2001 Apr 6;276(14):10745-52.
  • Pouwels J, Moracci M, Cobucci-Ponzano B, Perugino G, van der Oost J, Kaper T, Lebbink JH, de Vos WM, Ciaramella M, Rossi M. Activity and stability of hyperthermophilic enzymes: a comparative study on two archaeal beta-glycosidases. Extremophiles. 2000 Jun;4(3):157-64.
  • Napoli A, van der Oost J, Sensen CW, Charlebois RL, Rossi M, Ciaramella M. An Lrp-like protein of the hyperthermophilic archaeon Sulfolobus solfataricus which binds to its own promoter. J Bacteriol. 1999 Mar;181(5):1474-80.
  • Moracci M, Trincone A, Perugino G, Ciaramella M, Rossi M. Restoration of the activity of active-site mutants of the hyperthermophilic beta-glycosidase from Sulfolobus solfataricus: dependence of the mechanism on the action of external nucleophiles. Biochemistry. 1998 Dec 8;37(49):17262-70.
  • van der Oost J, Ciaramella M, Moracci M, Pisani FM, Rossi M, de Vos WM. Molecular biology of hyperthermophilic Archaea. Adv Biochem Eng Biotechnol. 1998;61:87-115. Review.
  • Aguilar CF, Sanderson I, Moracci M, Ciaramella M, Nucci R, Rossi M, Pearl LH. Crystal structure of the beta-glycosidase from the hyperthermophilic archeon Sulfolobus solfataricus: resilience as a key factor in thermostability. J Mol Biol. 1997 Sep 5;271(5):789-802.
  • Cocca E, Ratnayake-Lecamwasam M, Parker SK, Camardella L, Ciaramella M, di Prisco G, Detrich HW 3rd. Do hemoglobinless icefishes have globin genes?Comp. Biochem Physiol. 118A, 4, 1027-1030, 1997
  • Scudiero R, Capasso C, Carginale V, Riggio M, Capasso A, Ciaramella M, Filosa S, Parisi E. PCR amplification and cloning of metallothionein complementary DNAs in temperate and Antarctic sea urchin characterized by a large difference in egg metallothionein content. Cell Mol Life Sci. 1997 May;53(5):472-7.
  • Guagliardi A, Napoli A, Rossi M, Ciaramella M. Annealing of complementary DNA strands above the melting point of the duplex promoted by an archaeal protein. J Mol Biol. 1997 Apr 11;267(4):841-8.
  • Moracci M, Capalbo L, Ciaramella M, Rossi M. Identification of two glutamic acid residues essential for catalysis in the beta-glycosidase from the thermoacidophilic archaeon Sulfolobus solfataricus. Protein Eng. 1996 Dec;9(12):1191-5.
  • Morana A, Moracci M, Ottombrino A, Ciaramella M, Rossi M, De Rosa M. Industrial-scale production and rapid purification of an archaeal beta-glycosidase expressed in Saccharomyces cerevisiae. Biotechnol Appl Biochem. 1995 Dec;22 ( Pt 3):261-8.
  • Cocca E, Ratnayake-Lecamwasam M, Parker SK, Camardella L, Ciaramella M, di Prisco G, Detrich HW 3rd. Genomic remnants of alpha-globin genes in the hemoglobinless antarctic icefishes. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):1817-21.
  • Prisco A, Moracci M, Rossi M, Ciaramella M. A gene encoding a putative membrane protein homologous to the major facilitator superfamily of transporters maps upstream of the beta-glycosidase gene in the archaeon Sulfolobus solfataricus. J Bacteriol. 1995 Mar;177(6):1614-9.
  • Ciaramella M, Cannio R, Moracci M, Pisani FM, Rossi M. Molecular biology of extremophiles. World J Microbiol Biotechnol. 1995 Jan;11(1):71-84. doi: 10.1007/BF00339137.
  • Pollice A, Ciaramella M, Pulitzer JF. Saccharomyces cerevisiae multifunctional protein RAP1 binds to a conserved sequence in the Polyoma virus enhancer and is responsible for its transcriptional activity in yeast cells. FEBS Lett. 1993 May 24;323(1-2):77-82. PMID: 8388336 Free Article
  • Moracci M, La Volpe A, Pulitzer JF, Rossi M, Ciaramella M. Expression of the thermostable beta-galactosidase gene from the archaebacterium Sulfolobus solfataricus in Saccharomyces cerevisiae and characterization of a new inducible promoter for heterologous expression. J Bacteriol. 1992 Feb;174(3):873-82.
  • Ciaramella M, Rocco V, Pulitzer JF. Foreign transcriptional enhancers in yeast. II. Interplay of the polyomavirus transcriptional enhancer and Saccharomyces cerevisiae promoter elements. Nucleic Acids Res. 1988 Sep 26;16(18):8869-86.
  • Ciaramella M, Sacco M, Pulitzer JF. Foreign transcriptional enhancers in yeast. I. Interactions of papovavirus transcriptional enhancers and a quiescent pseudopromoter on supercoiled plasmids. Nucleic Acids Res. 1988 Sep 26;16(18):8847-68. Erratum in: Nucleic Acids Res 1988 Dec 9;16(23):11398-9.
  • La Volpe A, Ciaramella M, Bazzicalupo P. Structure, evolution and properties of a novel repetitive DNA family in Caenorhabditis elegans. Nucleic Acids Res. 1988 Sep 12;16(17):8213-31.
  • Pulitzer JF, Colombo M, Ciaramella M. New control elements of bacteriophage T4 pre-replicative transcription. J Mol Biol. 1985 Mar 20;182(2):249-63.

In memory of our dear colleague Maria Ciaramella, who inspired, mentored and supported all of us. All publications here